Colon cleansing causes the body to lose fluids quickly, which can lead to dehydration. To stay hydrated, fluids need to
be replaced, so it's recommended that you drink plenty of clear liquids right up to your colonoscopy procedure. It's also
important to stay hydrated after your procedure, so continue drinking liquids.
dosing instructions, which recommend taking each dose with an 8-oz glass of clear
liquid, you can ensure that you have replaced the proper amount of fluid. Drinking the recommended amount of liquid
also assists in the flushing process of OsmoPrep, resulting in a more effective preparation. If you have any questions
about how much to drink, ask your healthcare provider.
It is important to drink plenty of clear liquids before, during, and after the colon-prep process. A clear liquid is any beverage you can see through that does not contain red or purple colors.
- Water
- Apple juice
- Ginger ale
- Lemon-lime soda
- Sports drink (eg, Gatorade®*)
- Lemonade
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Important Safety Information about OsmoPrep
WARNINGS
There have been rare, but serious reports of acute phosphate nephropathy in patients who received oral sodium phosphate products for colon cleansing prior
to colonoscopy. Some cases have resulted in permanent impairment of renal function and some patients required long–term dialysis. While some
cases have occurred in patients without identifiable risk factors, patients at increased risk of acute phosphate nephropathy may include those with
increased age, hypovolemia, increased bowel transit time (such as bowel obstruction), active colitis, or baseline kidney disease, and those using
medicines that affect renal perfusion or function (such as diuretics, angiotensin converting enzyme [ACE] inhibitors, angiotensin receptor blockers
[ARBs], and possibly nonsteroidal anti–inflammatory drugs [NSAIDs]).
It is important to use the dose and dosing regimen as recommended (PM/AM split dose).
Please see full Prescribing Information for OsmoPrep, including BOXED WARNING.
OsmoPrep® (sodium phosphate monobasic monohydrate, USP, and sodium phosphate dibasic anhydrous, USP) Tablets are indicated for cleansing
of the colon as a preparation for colonoscopy in adults 18 years of age or older. Considerable caution should be advised before OsmoPrep is used in
patients with severe renal insufficiency, congestive heart failure, ascites, unstable angina, gastric retention, ileus, severe chronic constipation,
bowel perforation, toxic megacolon, gastric bypass or stapling surgery, or hypomotility syndrome. Use with caution in patients with impaired renal
function, patients with a history of seizures or at higher risk of seizure, patients with higher risk of cardiac arrhythmias, known or suspected electrolyte
disturbances (such as dehydration), or people taking drugs that affect electrolyte levels. Patients with electrolyte abnormalities such as
hypernatremia, hyperphosphatemia, hypokalemia, or hypocalcemia should have their electrolytes corrected before treatment with OsmoPrep.
OsmoPrep is contraindicated in patients with a known allergy or hypersensitivity to sodium phosphate salts or any of its ingredients, and in patients with
biopsy–proven acute phosphate nephropathy. In clinical trials, the most commonly reported adverse reactions (reporting frequency >3%) were
abdominal bloating, nausea, abdominal pain, and vomiting. It is recommended that patients receiving OsmoPrep be advised to adequately hydrate before,
during, and after the use of OsmoPrep.
*Gatorade is a registered trademark of the Stokely-Van Camp, Inc., Chicago, IL.
References
- Rex DK, Schwartz H, Goldstein M, et al. Safety and colon-cleansing efficacy of a new residue-free formulation of sodium phosphate tablets. Am J Gastroenterol. 2006;101:2594-2604.
- OsmoPrep Tablets [package insert]. Raleigh, NC: Salix Pharmaceuticals, Inc; 2011.